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Updated: Jan 13, 2026

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Can we escape from top-priority ESKAPE pathogens?

Lingbing Zeng1, YouJun Feng2, Minggui Wang3

  • 1Department of Laboratory Medicine and Branch of Gaoxin, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, People's Republic of China.

Emerging Microbes & Infections
|January 8, 2026
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Summary
This summary is machine-generated.

The ESKAPE pathogens are critical multidrug-resistant organisms driving the global antimicrobial resistance crisis. Combating these superbugs requires integrated strategies focusing on prevention, surveillance, and novel therapies.

Keywords:
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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) are critical-priority multidrug-resistant organisms.
  • These bacteria are major contributors to the global antimicrobial resistance crisis, increasing morbidity, mortality, and healthcare costs.
  • The ability of ESKAPE pathogens to evade conventional antibiotics complicates clinical management and infection control.

Conclusions:

  • Coordinated and sustained interventions are necessary to tackle the global threat of ESKAPE pathogens.
  • Progress in surveillance and novel therapies indicates a path forward.
  • A balanced emphasis on prevention, surveillance, and therapeutic innovation is essential for the next decade.