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Treatment Patterns and Healthcare Utilization on Pediatric Atopic Dermatitis With Allergic Comorbidities: A Japanese
Masaki Futamura1, Yumi Kang2, Ambrish Singh3
1Department of Pediatrics, NHO Nagoya Medical Center, Aichi, Japan.
The Journal of Dermatology
|January 8, 2026
Summary
Children with atopic dermatitis (AD) and allergic comorbidities (ACMs) face a higher clinical and economic burden. Real-world data show increased healthcare utilization and costs for pediatric AD patients with co-existing allergic conditions.
Area of Science:
- Pediatric Dermatology
- Allergy and Immunology
- Health Economics
Background:
- Atopic dermatitis (AD) is a chronic, pruritic skin condition often starting in infancy.
- High co-occurrence of allergic comorbidities (ACMs) like asthma, food allergy, and allergic rhinitis presents a significant public health challenge.
- Limited real-world data exist on treatment patterns and economic burden of pediatric AD, particularly concerning ACMs.
Purpose of the Study:
- To assess the clinical profiles and healthcare utilization of pediatric patients with AD.
- To evaluate the economic burden associated with AD in children, considering the presence of allergic comorbidities.
- To analyze treatment patterns for AD in children with and without ACMs.
Main Methods:
- Retrospective observational study utilizing the JMDC Claims database.
- Inclusion of children aged 0-6 years diagnosed with AD between January 2018 and September 2023.
- Analysis of 244,316 pediatric AD cases, comparing those with AD-only versus those with AD and ACMs.
Main Results:
- 82.3% of pediatric AD patients had co-existing ACMs, with allergic rhinitis being most prevalent.
- Patients with AD and ACMs exhibited higher healthcare utilization, including more outpatient visits and shorter hospital stays.
- Median annual healthcare costs were substantially higher for children with AD and ACMs (139,391 Yen) compared to AD-only (98,646 Yen), increasing with the number of ACMs.
Conclusions:
- The presence of allergic comorbidities significantly increases the clinical and economic burden in pediatric patients with atopic dermatitis.
- Treatment patterns, including the use of topical and systemic corticosteroids and antihistamines, differ between AD-only and AD with ACMs groups.
- Findings underscore the need for intensive management strategies and dedicated healthcare resources to address the multifaceted burden of pediatric AD with ACMs.
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