Related Experiment Video
Updated: Jan 13, 2026

Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model
Published on: April 2, 2017
Moringa oleifera ameliorates oxidative damage caused by sodium valproate in the small intestine
Melis Coremen1, Onur Ertik2, Umar Faruk Magaji3
1Faculty of Science, Department of Biology, Istanbul University, Istanbul, Türkiye.
Abstract:
This study aimed to investigate the protective effects of Moringa oleifera (MO) extract against valproic acid (VPA)-induced small intestine damage in rats. Forty-six adult female Sprague-Dawley rats were divided into four groups: Control (saline), MO (300 mg/kg), VPA (500 mg/kg), and VPA + MO. All treatments were administered orally for 15 days. Biochemical oxidative stress analyses revealed that MO treatment mitigated oxidative stress in VPA-treated rats. Molecular docking studies demonstrated that bioactive compounds in MO leaves exhibited potential inhibitory activity against oxidative stress-related enzymes, with high binding affinities. Immunohistochemical results indicated that VPA did not alter antioxidant stress responses such as Nrf2. However, histological examinations showed that VPA caused structural damage to the small intestine, while MO treatment alleviated this effect. Overall, MO exhibited significant protective and antioxidant properties against VPA-induced intestinal injury.
Related Concept Videos
Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems
Oxidation reactions are fundamental in aromatic carbon-containing systems. An example is the hydroxylation of phenobarbital, a process that transforms it into...
Prevention of Further Absorption of Poison
Overview of Metabolism
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Vitamins
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Oxidation of Alkenes: Syn Dihydroxylation with Potassium Permanganate