Related Experiment Video
Updated: Aug 15, 2026

Multi-scale Analysis of Bacterial Growth Under Stress Treatments
Published on: November 28, 2019
Effect of cerulenin on Streptococcus faecalis macromolecular synthesis and cell division
Abstract:
The antibiotic cerulenin has been used to study macromolecular synthesis and cell division in Streptococcus faecalis. The data suggest that lipid and lipoteichoic acid synthesis as well as cell number increase are affected prior to any observable effects on overall mass increase or DNA, RNA, protein, or peptidoglycan synthesis. Treatment with cerulenin of cultures growing at various rates and analysis of the subsequent cell divisions indicate that the antibiotic may block a cell cycle event that precedes the completion of chromosome replication by about 10 min.
Related Concept Videos
Stringent Response in E. coli
Inhibitors of Gram-positive Cell Wall Synthesis
Inhibitors of Bacterial Protein Synthesis

