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Trace Element Nanoparticles for Neurodegenerative Disease Therapy.
Pi-Cheng Ying1, Qiu-Ju Han1, Xiao-Jie Chen1
1Zhejiang Collaborative Innovation Center for the Brain Diseases with Integrative Medicine, Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 310053 Hangzhou, Zhejiang, China.
Trace-element imbalances contribute to neurodegenerative diseases (NDDs). Nanoparticle-based therapies offer a precision approach to NDD treatment by targeting the brain and delivering therapeutic payloads effectively.
Area of Science:
- Biomedical Engineering
- Nanomedicine
- Neuroscience
Background:
- Neurodegenerative diseases (NDDs) are linked to oxidative stress, neuroinflammation, and neuronal death, often involving cerebral trace-element imbalances.
- Trace elements possess redox, anti-inflammatory, and pro-survival properties beneficial for NDD interventions.
Purpose of the Study:
- To provide a comprehensive overview of trace-element-based nanotherapeutics for NDDs.
- To explore the role of trace-metal imbalances in NDD pathogenesis.
- To evaluate nanoparticle construction, advantages, and safety for NDD treatment.
Main Methods:
- Review of existing literature on trace-element nanotherapeutics in NDDs.
- Analysis of nanoparticle design for blood-brain barrier penetration and targeted delivery.
- Discussion of trace-element metabolism and inflammation in the context of NDDs.
Main Results:
- Trace-element nanotherapeutics show significant potential in NDD treatment.
- Nanoplatforms enable precision delivery and on-demand payload release.
- Systematic studies on nanotherapeutic applications in NDDs are limited.
Conclusions:
- Trace-element nanotherapeutics represent a promising precision nanomedicine strategy for NDDs.
- Further research is needed to guide the design and development of these therapies.
- Comprehensive safety evaluation of trace-element nanoparticles is crucial for clinical translation.
