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Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
Published on: September 23, 2022
Evaluating the Mechanisms of Action of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Ischemic Stroke
Jianzhong Shu1,2,3, Qianqian Liang3,4, Xiaohong He3,4
1Department of Encephalopathy, Chongqing Hospital of Traditional Chinese Medicine, 400015 Chongqing, China.
Abstract:
The utilization of cell-free therapies derived from extracellular vesicles (EVs) has garnered mounting interest as a promising approach to address the myriad challenges associated with ischemic stroke. These Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) possess considerable therapeutic potential due to their inherent properties, including low immunogenicity, efficient cargo transportation, and the ability to cross the blood-brain barrier. This review examines the mechanisms underlying mesenchymal stem cell-derived EVs in the treatment of ischemic stroke. Future research should aim to identify optimal strategies for EV-based interventions, including combination therapy and preconditioning strategies.
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