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    The Patient-Centered Outcomes Research Network (PCORnet) is a vital clinical research infrastructure. It enables large-scale, patient-centered studies and continuously evolves to meet research needs.

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    Area of Science:

    • Health Services Research
    • Clinical Effectiveness Research
    • Health Informatics

    Background:

    • PCORnet is a large, federated
    • network of networks
    • facilitating patient-centered comparative effectiveness research (CER) nationally.

    Purpose of the Study:

    • To present the Patient-Centered Outcomes Research Institute's (PCORI) perspective on clinical research infrastructure.
    • To highlight PCORnet's unique contributions to patient-centered research.
    • To outline PCORI's strategy for PCORnet's ongoing evaluation and development.

    Main Methods:

    • This is a commentary, not a research study.
    • It presents PCORI's viewpoint and strategic approach.
    • No specific research methods were employed.

    Main Results:

    • PCORnet's scale (47M+ patients) and infrastructure support diverse study types.
    • PCORnet has facilitated over 250 studies since 2015.
    • Continuous evaluation ensures PCORnet's effectiveness and evolution.

    Conclusions:

    • Clinical research infrastructure is crucial for advancing patient-centered outcomes.
    • PCORnet is a unique and valuable national asset for health research.
    • PCORI's commitment to evaluation ensures PCORnet's sustained impact.