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Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Study Designs in Epidemiology01:20

Study Designs in Epidemiology

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Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
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Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Nursing Clinical Information System01:27

Nursing Clinical Information System

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Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
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Study Design in Statistics01:15

Study Design in Statistics

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A study design is a set of techniques that allow a researcher to collect and analyze data from different variables defined for a specific research problem. Statistics is commonly for effective study design and more robust experiments,
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
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Preclinical Development: Overview01:28

Preclinical Development: Overview

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Updated: Jan 13, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
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PCORnet®: An Infrastructure Supporting Innovation in Clinical Study Design.

Adrian F Hernandez1, Elizabeth Shenkman2, Kathleen McTigue3

  • 1Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC.

Medical Care
|January 8, 2026
PubMed
Summary
This summary is machine-generated.

The Patient-Centered Outcomes Research Network (PCORnet) infrastructure supports efficient, patient-centered health research. Over 300 studies utilized PCORnet, with 58 recognized as meritorious PCORnet® Studies, demonstrating its impact on research quality.

Keywords:
PCORnetclinical researchclinical trialsreal-world data

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Area of Science:

  • Health Services Research
  • Clinical Research Infrastructure
  • Patient-Centered Outcomes Research

Background:

  • PCORnet, funded by the Patient-Centered Outcomes Research Institute, is a national resource for efficient health research.
  • The PCORnet infrastructure supports diverse study designs and serves as a model for patient-centered research.
  • A subset of studies, PCORnet® Studies, meet specific criteria for quality and impact.

Purpose of the Study:

  • To explore the utilization and impact of the PCORnet infrastructure over the past decade.
  • To highlight study archetypes, clinical areas, funding, and institutional users within PCORnet.
  • To identify lessons learned and unique capabilities for future research innovation.

Main Methods:

  • Review of studies completed using the PCORnet infrastructure.
  • Analysis of meritorious PCORnet® Studies based on defined criteria.
  • Exploration of study characteristics including therapeutic areas and funding sources.

Main Results:

  • Over 300 studies completed using PCORnet infrastructure in the last 10 years.
  • 58 studies designated as meritorious PCORnet® Studies, with 19 completed.
  • Diverse clinical areas and funding sources represented across PCORnet studies.

Conclusions:

  • The PCORnet infrastructure effectively supports a wide range of patient-centered research.
  • Accumulated experience provides lessons for a continuously learning research framework.
  • PCORnet capabilities foster innovation for future clinical trials and research endeavors.