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Related Experiment Video

Updated: Jun 13, 2026

Development and Implementation of a Multi-Disciplinary Technology Enhanced Care Pathway for Youth and Adults with Concussion
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Development and Value of a Centralized Text Message-based Tracking and Support Program for the PRECIDENTD Study.

Lyndsay A Nelson1, Erin M Bergner1, Amos Adler2

  • 1Department of Medicine, Division of General Internal Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN.

Medical Care
|January 8, 2026
PubMed
Summary
This summary is machine-generated.

A text messaging program successfully engaged participants in a study on diabetes medications, identifying 25% who needed help with adherence. This digital tool improved retention and support for patients in clinical research.

Keywords:
adherencecomparative studiesrandomized trialtechnology

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Area of Science:

  • Comparative effectiveness research
  • Digital health interventions
  • Type 2 Diabetes management

Background:

  • The PRECIDENTD study investigates SGLT2 inhibitors and GLP-1 receptor agonists for cardiovascular and kidney disease prevention in type 2 diabetes.
  • Participants receive study medications via insurance and complete regular assessments.

Purpose of the Study:

  • To develop and evaluate a centralized, text message-based program to enhance participant adherence and retention in the PRECIDENTD study.
  • To assess the performance of the digital health tool over a one-year period.

Main Methods:

  • A text messaging program was co-designed with patient partners and a technology company, incorporating best practices in digital health.
  • The program featured interactive messages about medication adherence and one-way informational messages.
  • Participant responses were analyzed to determine engagement and identify adherence challenges.

Main Results:

  • The text messaging program reached 450 participants across 20 sites in its first year.
  • An 80% response rate was achieved for interactive adherence messages.
  • Twenty-five percent of responses flagged issues such as medication access or side effects, triggering outreach.

Conclusions:

  • A co-designed digital tool effectively engaged participants and identified those needing support with medication adherence.
  • Centralized digital tools developed collaboratively can enhance the capacity of national studies for comparative effectiveness research.