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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
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Full-house nephropathy associated with mantle cell lymphoma
Keiichiro Kinoshita1, Kenichi Koga1, Kensei Yahata2
1Department of Nephrology, Japanese Red Cross Osaka Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, Osaka, 543-8555, Japan.
CEN Case Reports
|January 8, 2026
Summary
Mantle cell lymphoma (MCL) can cause nephrotic syndrome and acute kidney injury by mimicking lupus nephritis. Prompt MCL treatment improved the patient's renal function, highlighting the importance of identifying secondary glomerulonephritis.
Area of Science:
- Nephrology
- Oncology
- Immunology
Background:
- Mantle cell lymphoma (MCL) is a rare B-cell non-Hodgkin lymphoma.
- Kidney involvement in MCL is uncommon but can manifest as glomerulonephritis.
- Distinguishing lymphoma-associated glomerulonephritis from primary kidney diseases is crucial for effective treatment.
Purpose of the Study:
- To report a rare case of immune complex-associated glomerulonephritis secondary to mantle cell lymphoma.
- To highlight the clinical presentation and diagnostic challenges of MCL-induced kidney disease.
- To emphasize the importance of considering secondary causes of glomerulonephritis in elderly patients with lymphoma.
Main Methods:
- Case report of an 82-year-old male patient.
- Clinical evaluation including physical examination, laboratory tests (renal function, complement levels, autoantibodies), and imaging (CT scan).
- Histopathological examination of renal and bone marrow biopsies.
Main Results:
- The patient presented with nephrotic syndrome and acute renal failure.
- Renal biopsy revealed full-house glomerulonephritis with immune deposits, resembling lupus nephritis.
- Bone marrow biopsy confirmed mantle cell lymphoma; lymphoma cells infiltrated the renal interstitium.
- Treatment of MCL led to improvement in renal function and proteinuria.
Conclusions:
- Immune complex-associated glomerulonephritis can be a paraneoplastic manifestation of mantle cell lymphoma.
- This condition can mimic systemic lupus erythematosus, necessitating thorough investigation.
- Early diagnosis and treatment of the underlying lymphoma are critical for renal recovery.
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