Response of Pancreatic Stellate Cells to the Development of Experimental Type 2 Diabetes Mellitus
T R Sultanova1, E A Mukhlynina2, I F Gette2
1Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russia. Tatiana.Sultanova.97@yandex.ru.
Abstract:
Pancreatic stellate cells (PSCs) are involved in the homeostasis maintenance in the pancreas, but upon activation, they are capable of excessive production of extracellular matrix proteins, which can aggravate the course of the pathological process, in particular diabetes. The changes in the functional activity of PSCs in the acinar and islet parts of the pancreas in rats with experimental type 2 diabetes mellitus were assessed by the expression of GFAP and α-SMA markers, as well as by the intensity of collagen proportion. During the development of experimental type 2 diabetes mellitus, PSCs are activated in the pancreas as evidenced by enhanced expression of α-SMA accompanied by increased collagen production. We revealed a direct correlation of the levels of glucose and HbA1c with relative collagen content in the islets and the number of α-SMA+ cells. The results obtained can further contribute to the development of therapeutic strategies for the treatment of type 2 diabetes mellitus.
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