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Related Experiment Video

Updated: Jan 13, 2026

A Rapid In Vivo Bioassay for Developmentally Active Enhancers
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YAP-TEAD regulates the super-enhancer network to control early surface ectoderm commitment.

Zhiming Wang1,2, Chen Yang1, Ziyue Ma1

  • 1Department of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Nucleic Acids Research
|January 8, 2026
PubMed
Summary
This summary is machine-generated.

Super enhancers (SEs) are key to cell identity. This study reveals how SEs and YAP-TEAD signaling control surface ectoderm differentiation, offering insights for stem cell therapies.

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Area of Science:

  • Genomics
  • Stem Cell Biology
  • Developmental Biology

Background:

  • Super enhancers (SEs) are critical for cellular identity and function.
  • Understanding SEs in surface ectoderm differentiation is vital for regenerative medicine.

Purpose of the Study:

  • To profile the SE landscape in surface ectoderm cells derived from pluripotent stem cells.
  • To investigate the regulatory network controlling SEs and their role in differentiation.
  • To identify key regulators of surface ectoderm commitment.

Main Methods:

  • Profiling SE landscape using 3D genomics.
  • CRISPR-dCas9 for SE perturbation.
  • Analysis of transcription factor regulatory networks.
  • Investigating YAP-TEAD signaling pathway.

Main Results:

  • Identified active histone modifications and chromatin interactions of SEs.
  • Perturbing SEs decreased target gene expression.
  • Uncovered a regulatory network involving core TFs and TEAD1.
  • YAP-TEAD activation expedited differentiation and SE establishment.

Conclusions:

  • SEs play a crucial role in surface ectoderm lineage commitment.
  • YAP-TEAD signaling is a vital regulator of this process.
  • Findings provide insights into lineage commitment and stem cell-based epithelial regeneration.