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Updated: Jan 13, 2026
Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases
Published on: December 6, 2016
Clinical and Imaging Features of Dynamic Evolution after Reperfusion-Related Intracerebral Hemorrhage (DESIRE):
Yunxiu Huang1, Zhimeng Zhang1, Yanan Wang1
1Department of Neurology, Center of Cerebrovascular Diseases, West China Hospital, Sichuan University, Chengdu, China.
Introduction:
Intracerebral hemorrhage (ICH) is a common complication of reperfusion treatment (thrombolysis and/or thrombectomy) after acute ischemic stroke, which is related to poor outcomes. Recent data suggest that reperfusion-related ICH may be dynamic and experience hemorrhage expansion. However, the underlying pathophysiology, natural history, outcomes, clinical features, and risk factors associated with the dynamic evolution of reperfusion-related ICH remain poorly understood.
Methods:
The dynamic evolution after reperfusion-related ICH (DESIRE) is a prospective observational cohort study, which is designed to investigate the natural history of the dynamic evolution after reperfusion-related ICH and its clinical and imaging risk factors related to the evolution and progression. Patients with acute ischemic stroke admitted to the Department of Neurology, West China Hospital, Sichuan University in China and received reperfusion therapy will be included. Baseline data, clinical characteristics, as well as major laboratory measures will be collected after admission. All patients will complete brain CT on admission, at 1 day, 3 days, 7 days, with neurological deterioration during hospitalization. We will assess qualitative imaging markers and radiomic features on non-contrast-enhanced computed tomography imaging brain images. The primary outcome is the dynamic evolution after reperfusion-related ICH, which includes one of the following conditions: (1) hematoma expansion: a 33% increase in the hematoma volume using the (A*B *C)/2 method on follow-up imaging; or (2) hemorrhagic infarction evolving into parenchymal hematoma; or (3) asymptomatic ICH evolving into symptomatic ICH. Patients will be followed up at 3 months, 6 months, and 1 year by phone to investigate their survival status, functional outcomes, and cognitive status assessed by modified Rankin Scale score and the modified Telephone Interview for Cognitive Status.
Conclusion:
The dynamic evolution after reperfusion-related ICH is poorly understood, as well as the risk factors that drive this progression. This study investigates the natural history of the dynamic evolution after reperfusion-related ICH, identifies those at high risk of early evolution and progression, and uncovers novel targets for prevention and therapy.
