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  1. Home
  2. Epicoccum Nigrum As A Valuable Source Of Natural Products For Agricultural And Biotechnological Applications.
  1. Home
  2. Epicoccum Nigrum As A Valuable Source Of Natural Products For Agricultural And Biotechnological Applications.

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Epicoccum nigrum as a valuable source of natural products for agricultural and biotechnological applications.

Daria Lotito1, Alessia Staropoli1, Maria Michela Salvatore1

  • 1Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Napoli, Italy.

Natural Product Research
|January 8, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

The fungal endophyte Epicoccum nigrum shows potential as a biocontrol agent, inhibiting Fusarium verticillioides growth. It produces bioactive compounds like Epipyrone A, aiding sustainable plant disease management.

Keywords:
Beneficial microbesendophyteepicoccamide Aepipyrone A

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Area of Science:

  • Agricultural Science
  • Mycology
  • Biotechnology

Background:

  • Fungal endophytes can produce bioactive compounds.
  • Plant diseases caused by fungal phytopathogens lead to significant crop losses.
  • Biocontrol agents offer sustainable alternatives to chemical pesticides.

Purpose of the Study:

  • To evaluate the antagonistic activity of Epicoccum nigrum against fungal phytopathogens.
  • To identify and characterize the bioactive secondary metabolites produced by E. nigrum.
  • To explore the potential of E. nigrum as a biocontrol agent for sustainable agriculture.

Main Methods:

  • Isolation and identification of Epicoccum nigrum from Avena sativa.
  • Dual culture bioassays to assess antagonistic activity against Fusarium verticillioides and Alternaria alternata.
  • Purification and structural elucidation of secondary metabolites using HPLC, mass spectrometry, and NMR techniques.
  • Main Results:

    • Epicoccum nigrum significantly inhibited the radial growth of Fusarium verticillioides (up to 66.8% after 15 days).
    • Weak inhibition was observed against Alternaria alternata.
    • Epipyrone A and epicoccamide A were identified as major secondary metabolites.

    Conclusions:

    • Epicoccum nigrum exhibits antagonistic properties against key fungal phytopathogens.
    • The production of bioactive compounds suggests potential for biocontrol applications.
    • Further research is necessary to fully understand the mechanisms and optimize the use of E. nigrum in plant disease management.