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Updated: Jan 13, 2026
Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
Published on: March 6, 2019
Lung ultrasound features during the evolution of BPD: a study from an animal model
Haifeng Zong1,2, Cuihui Li1, Nan Ye1
1Neonatal Intensive Care Unit, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University, Shenzhen, Guangdong Province, China.
Objective:
To explore lung ultrasound (LUS) in the evolution of bronchopulmonary dysplasia (BPD) and the diagnostic value of LUS in BPD.
Methods:
Newborn rats were randomly assigned to the room air (RA) group or the oxygen (O2) group. LUS were performed at 12 h and on the 3rd, 7th, and 10th days to explore the LUS in BPD rats. Hematoxylin-eosin staining and immunohistochemical were analyzed to evaluate pathological characteristics.
Results:
LUS score (LUSs) in the O2 group was significantly increased on the 7th and 10th days. In the early stage, LUS revealed multiple B-lines and air bronchograms. In the late stage, LUS revealed anechoic echoic areas on the pleural surface and scattered dot-like hyperechoic patterns in the lung field. The LUS findings were consistent with the pathological results.
Conclusion:
There was a strong positive correlation between LUS and pathological findings. LUS can be used to monitor the evolution of BPD.
