Related Experiment Video
Updated: Jan 13, 2026
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Macular cone cell mosaic metrics in myopia: severity evaluation and diagnostic efficiency using adaptive optics
Ke-Yu Liu1, Ju-Xian Liu1, Zhou-Yu Li1
1The First Affiliated Hospital of Chongqing Medical University, Department of Ophthalmology, Chongqing Key Laboratory of Prevention and Treatment of Major Blinding Diseases, Chongqing Eye Institute, Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, China.
Objectives:
To quantify macular cone cell mosaic metrics in patients with varying degrees of myopia and explore its link to myopia severity using an adaptive optics (AO) fundus camera.
Methods:
A total of 76 age- and gender-matched patients with varying degrees of myopia (pre-myopia, low, moderate, and high) were recruited. Macular cone cell mosaic metrics (density, spacing, regularity, dispersion) were quantified via adaptive optics (AO) imaging, including correlations between AO-derived parameters and clinical indicators (spherical equivalent refraction, axial length) and predictive efficacy of AO metrics for myopia severity evaluated through receiver operating characteristic (ROC) curve analysis.
Results:
As spherical equivalent refraction (SER) decreased, cone density (r = 0.65) and regularity (r = 0.38) significantly declined, while spacing (r = -0.65) and dispersion (r = -0.40) increased (all P < 0.001). Axial length (AL) was negatively correlated with density (r = -0.62) and regularity (r = -0.39), and positively correlated with spacing (r = 0.61) and dispersion (r = 0.38) (all P < 0.001). Predictive efficacy analysis based on AO-derived parameters revealed the highest AUROC value in the HM group (0.96), followed by Pre-M (0.86), LM (0.82), and MM (0.65) groups, indicating that AO metrics demonstrated superior early identification capability for HM severity.
Conclusions:
The AO fundus camera enables noninvasive evaluation of macular cone cell mosaic metrics, revealing strong correlations between density, regularity, spacing, dispersion, and myopia severity. These metrics demonstrate potential as biomarkers for evaluating myopic changes, with AO showing enhanced diagnostic efficacy in high myopia.
