Related Experiment Video
Updated: Jan 13, 2026

Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity
Published on: September 21, 2021
Aglodorols A-J, undescribed terpenoids with multidimensional neuroprotective activities from Aglaia odorata Lour
Meng Ding1, Yue-Han Wang1, Chen-Hao Liu1
1State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China.
Abstract:
Three unprecedented triterpenoids (1-2, 8), seven novel diterpenoids (13-16, 19-21), and 12 known compounds (3-7, 9-12, 17-18, 22) were isolated from the tender branches and leaves of Aglaia odorata Lour. Structural elucidation was achieved through integrated spectroscopic analysis, quantum chemical calculations (NMR/ECD), and single-crystal X-ray diffraction. All isolates were evaluated for neuroprotective effects. Compounds 3, 9-11, 13, 17, and 18 showed significant protective effects against oxygen-glucose deprivation/reperfusion (OGD/R)-mediated nerve injury in PC12 cells at 10 µM, while compounds 3 and 19 exhibited potent anti-excitotoxicity activity in the L-glutamate-induced HT22 cells at 20 µM. Strikingly, triterpenoids 1, 2, and 11 displayed remarkable activity against RSL3-induced PC12 cell death with EC50 values ranging from 1.16 to 1.74 μM. Compound 22 exhibited the most significant inhibitory activity among the isolates against nitric oxide (NO) release in lipopolysaccharide (LPS)-activated BV2 cells with an IC50 value of 22.41 µM.
More Related Videos
07:59A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
11:44Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
Published on: January 19, 2022
Related Concept Videos
Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
Olfactory Receptors: Location and Structure
Aromatic Compounds: Overview
In 1825, Faraday isolated...
Local Anesthetics: Chemistry and Structure-Activity Relationship
Aromatic Hydrocarbon Anions: Structural Overview
Due to the absence of continuous...
Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...