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Effect Of Process And Formulation Variables On Quality, Stability, And Taste Of Lamivudine Printlets Manufactured By Binder Jetting 3d Printing Method.

Home
Research Domains
Engineering
Manufacturing Engineering
Precision Engineering
Effect Of Process And Formulation Variables On Quality, Stability, And Taste Of Lamivudine Printlets Manufactured By Binder Jetting 3d Printing Method.

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Effect of Process and Formulation Variables on Quality, Stability, and Taste of Lamivudine Printlets Manufactured by Binder Jetting 3D Printing Method.

Tahir Khuroo¹, Linh H Maracchini¹, Ziyaur Rahman¹

¹Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Texas A&M University, Reynolds Medical Sciences Building, Suite 308, College Station, TX, 77843, USA.

AAPS Pharmscitech

|January 8, 2026

View abstract on PubMed

Summary

This summary is machine-generated.

Keywords:

assay binder jetting 3D printing dissolution lamivudine

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Binder jetting 3D printing successfully produced lamivudine printlets with controlled quality attributes. This 3D printing method offers a viable approach for personalized medication manufacturing.

Area of Science:

Pharmaceutical Technology
3D Printing
Drug Delivery

Background:

3D printing offers potential for personalized medicine.
Binder jetting is an additive manufacturing technique suitable for pharmaceutical applications.

Purpose of the Study:

To investigate the impact of formulation and process variables on lamivudine printlet quality using binder jetting.
To assess critical quality attributes including hardness, disintegration time, and dissolution.

Main Methods:

Fractional factorial design of experiments was employed.
Variables included solvent sprays, delay time, powder layer thickness, drying temperature, and hydroxypropyl methylcellulose percentage.
Printlets were characterized using hardness testing, disintegration time, dissolution testing, X-ray powder diffraction (XRPD), near-infrared hyperspectroscopy, and electronic tongue.

Main Results:

Printlet hardness ranged from 2.5 to 21.1 N, and disintegration time (DT) from 2.3 to 317 seconds.
Dissolution profiles met United States Pharmacopeia (USP) specifications (>85% drug dissolved in 30 min).
XRPD indicated partial drug amorphization, hyperspectroscopy confirmed uniform component distribution, and excipients mitigated drug bitterness.

Conclusions:

Binder jetting is a suitable method for manufacturing lamivudine printlets with controlled quality.
The study demonstrated the feasibility of producing personalized medications with robust quality control using this 3D printing technique.