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Updated: Jan 13, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

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Neurovascular and metabolic dysfunction with cell type-specific transcriptomic changes in presymptomatic 5XFAD mice

Minmin Yao¹, Na Sun^2,3, Raleigh Linville^4,5

¹Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, CMSC 8-121, 600 North Wolfe Street, Baltimore, MD, 21287, USA.

Fluids and Barriers of the CNS

|January 8, 2026

Summary

No abstract available in PubMed .

Keywords:

Alzheimer’s disease Blood brain barrier Cerebral metabolism Neuroimaging biomarkers Single cell transcriptomics

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