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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Related Experiment Video

Updated: Jan 13, 2026

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
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Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice.

Sarah Morsy1, Enzo Scifo1, Kan Xie1

  • 1Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

Aging Cell
|January 9, 2026
PubMed
Summary
This summary is machine-generated.

Aging causes widespread gene expression changes in organs, varying by tissue and timing. This study maps these transcriptomic shifts across the mouse lifespan, revealing key aging signatures.

Keywords:
agingmouse organsqPCRtrajectoriestranscriptomics

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Area of Science:

  • Genomics
  • Aging Research
  • Systems Biology

Background:

  • Aging is a primary risk factor for many diseases.
  • Transcriptional alterations in organs are hallmarks of aging.
  • The precise timing and scope of these changes remain incompletely understood.

Purpose of the Study:

  • To comprehensively map age-related transcriptomic changes across multiple organs throughout the murine lifespan.
  • To identify tissue-specific and shared aging signatures.
  • To provide a systems-level resource for aging research.

Main Methods:

  • Bulk RNA sequencing was performed on eight organs from male C57BL/6J mice at six different ages (3, 5, 8, 14, 20, and 26 months).
  • Data analysis involved identifying age-related transcriptomic shifts, their timing, and extent.
  • A linear mixed-effects model was used to determine tissue-specific aging trajectories, complemented by hub gene analysis and functional enrichment.

Main Results:

  • Significant age-related transcriptomic shifts were observed, with distinct timing and extents across organs (e.g., early in lung, spleen, testis; mid-life in heart, kidney, skeletal muscle; later in brain, liver).
  • The magnitude of transcriptomic changes varied considerably, from low in the testis to high in the kidney, liver, and spleen.
  • Identified aging signatures included pathways related to immune response, mitochondrial dysfunction, extracellular matrix remodeling, and cellular senescence, with both tissue-specific and shared patterns.

Conclusions:

  • Transcriptomic aging is a complex, multi-organ process with diverse temporal dynamics and magnitudes.
  • This study provides a detailed map of aging-related gene expression changes in mice, highlighting conserved and organ-specific molecular pathways.
  • The findings offer a valuable resource for understanding aging mechanisms and developing interventions for age-related diseases.