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Updated: Jan 13, 2026
Isolation of Human Islets from Partially Pancreatectomized Patients
Published on: July 30, 2011
Long Term Metabolic Outcomes Following Pancreatectomy and Autologous Islet Transplantation: Systematic Review and
Daniel L Hughes1, Caterina Di Bella2,3, Benedetta Quaratino2,3
1Department of Hepato-Pancreato-Biliary Surgery, Oxford University Hospitals NHS Foundation trust, Oxford.
None:
This systematic review and meta-analysis assessed long-term outcomes following total pancreatectomy with islet autotransplantation (TPIAT). Seventeen studies including 1332 patients were analyzed. The pooled insulin independence rate was 34%, with higher rates for non-chronic pancreatitis indications (68%) versus chronic pancreatitis (33%). TPIAT is effective in preserving endocrine function. Further studies are needed to validate outcomes across extended indications and to standardize reporting, incorporating metabolic markers and patient-reported quality-of-life endpoints over long-term follow-up.
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