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Related Concept Videos

Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

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Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
331
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

444
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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A Modified Cuff Technique for Mouse Cervical Heterotopic Heart Transplantation Model
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Heart Transplantation in Patients With Systemic Sclerosis.

Morgan D Smith1, Miroslav Sekulic2, Matthew Regan1

  • 1Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York-Presbyterian Hospital, New York, New York, USA.

Clinical Transplantation
|January 9, 2026
PubMed
Summary
This summary is machine-generated.

Heart transplant (HT) in systemic sclerosis (SSc) patients shows good mid-term graft function. Despite increased rejection rates, HT is feasible for carefully selected SSc patients with advanced heart failure.

Keywords:
auto‐immune diseasesdiffusegraft rejectiongraft survivalheart transplantationpathologysclerodermasurgicalsystemic

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Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Rheumatology

Background:

  • Systemic sclerosis (SSc) is a multisystem disease often leading to heart failure (HF).
  • Heart transplant (HT) is the definitive treatment for advanced HF.
  • Outcomes of HT in SSc patients are not well-characterized.

Purpose of the Study:

  • To report the outcomes of heart transplant (HT) in patients with systemic sclerosis (SSc).

Main Methods:

  • Retrospective analysis of HT recipients with SSc from 2007-2024 at two transplant centers.
  • Collected baseline characteristics, admission data, and post-HT outcomes from electronic medical records.
  • Pathology of explanted hearts and allograft biopsies reviewed by a dedicated pathologist.

Main Results:

  • Seven SSc patients underwent HT (six heart-only, one heart-lung).
  • Median follow-up was 3.2 years; 86% had preserved ejection fraction.
  • Incidence of rejection included acute cellular rejection (ACR) and antibody-mediated rejection (AMR); one patient experienced graft failure.

Conclusions:

  • Heart transplant (HT) in SSc patients demonstrates good mid-term graft function.
  • An increased incidence of rejection was observed.
  • HT is feasible in carefully selected SSc candidates with advanced heart failure.