Related Experiment Video
Updated: Jan 13, 2026
03:57
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
2.3K
Trends in Clinical Features of Primary Hyperparathyroidism During 2013-2024
Yuansi Chen1, Junhe Wang1, Shuo Li1
1Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China, tjmugh.com.cn.
International Journal of Endocrinology
|January 9, 2026
Summary
Clinical features of primary hyperparathyroidism (PHPT) are changing in China, with more asymptomatic cases and milder symptoms observed over time. This trend suggests a shift towards earlier detection and management of PHPT in the Chinese population.
Area of Science:
- Endocrinology
- Oncology
- Public Health
Background:
- Primary hyperparathyroidism (PHPT) presents differently across regions, with limited large-scale data from China.
- Understanding evolving clinical patterns of PHPT in China is crucial for public health.
- Recent changes in PHPT presentation necessitate updated clinical insights.
Purpose of the Study:
- To describe the changing clinical features of primary hyperparathyroidism (PHPT) in Chinese patients.
- To analyze trends in PHPT presentation and pathology over a recent decade.
Main Methods:
- Retrospective analysis of 685 PHPT patients diagnosed between 2013 and 2024.
- Patients were subgrouped by time period, symptoms, and pathological findings.
- Clinical characteristics, biochemical markers, and bone mineral density were compared across subgroups.
Main Results:
- A significant increase in asymptomatic PHPT cases was observed from 2013-2018 to 2019-2024.
- Asymptomatic patients exhibited milder clinical manifestations and fewer complications.
- Malignant parathyroid tumors showed significantly elevated PTH, calcium, and alkaline phosphatase levels compared to benign tumors.
Conclusions:
- Clinical features of PHPT in China have evolved, characterized by a rise in asymptomatic cases with milder symptoms.
- These findings highlight a potential shift towards earlier diagnosis and management of PHPT.
- Further research into the factors driving these changes is warranted.
Related Concept Videos
00:59The Parathyroid Glands
4.3K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
4.3K
01:40Bone Remodeling
40.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.2K
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
363
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
363
01:24Chronic Kidney Disease II: Clinical Manifestations
543
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
543
01:17Hormones and Bone Tissue
3.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.7K
01:30Current Trends in Nursing II
3.3K
Trends in nursing are multifactorial and associated with changes in society, within the nursing profession, and in other professions. Notably, telehealth and remote nursing contribute to successful healthcare delivery for numerous patients and help reduce stress for nurses due to nursing shortages. Nurses can reach patients, monitor their conditions, and interact with them using computers, audio, visual accessories, and telephones—for example, remote patient monitoring systems. Likewise,...
3.3K