Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cross-reactivity00:42

Cross-reactivity

32.8K
Overview
32.8K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.3K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.3K
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.4K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.4K
Antigen Processing Pathways01:31

Antigen Processing Pathways

2.1K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
2.1K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

11.9K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
11.9K
Transcytosis of IgG01:15

Transcytosis of IgG

4.0K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Post-Translational Modifications Modulate the HLA-DR3 Restricted Epitope Landscape of Sjögren's Associated Autoantigens.

Medicina (Kaunas, Lithuania)·2026
Same author

Selective inhibition of respiratory complex I reveals a bioenergetic vulnerability in <i>Francisella</i>.

bioRxiv : the preprint server for biology·2026
Same author

Identification of functional genetic components modulating toxicity response to PFOS using genome-wide CRISPR screens in HepG2/C3A cells.

Archives of toxicology·2026
Same author

Elevated Levels of IL-9 Fail to Suppress Pathogenic T helper 17 cells in Sjögren's Disease.

medRxiv : the preprint server for health sciences·2026
Same author

Identification of Functional Genetic Components Modulating Toxicity Response to PFOS using Genome-wide CRISPR Screens in HepG2/C3A cells.

bioRxiv : the preprint server for biology·2025
Same author

Translating Features to Findings: Deep Learning for Melanoma Subtype Prediction.

Dermatopathology (Basel, Switzerland)·2025

Related Experiment Video

Updated: Jan 13, 2026

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

715

Discover Potential New Epitopes through Post-Translational Modification in Sjögren's Disease.

Danmeng Li, Alexandria Voigt, Cuong Nguyen

    Biorxiv : the Preprint Server for Biology
    |January 9, 2026
    PubMed
    Summary

    Post-translational modifications (PTMs) can alter how Sjögren's syndrome (SjD) autoantigens bind to HLA-DR3. PTM-mimic peptides showed enhanced T cell responses, suggesting a role in SjD immunogenicity.

    More Related Videos

    A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue
    09:42

    A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue

    Published on: June 7, 2017

    12.0K
    Antibody Binding Specificity for Kappa (V&#954;) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
    11:10

    Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

    Published on: June 29, 2016

    14.5K

    Related Experiment Videos

    Last Updated: Jan 13, 2026

    Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
    10:21

    Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

    Published on: September 20, 2024

    715
    A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue
    09:42

    A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue

    Published on: June 7, 2017

    12.0K
    Antibody Binding Specificity for Kappa (V&#954;) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
    11:10

    Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

    Published on: June 29, 2016

    14.5K

    Area of Science:

    • Immunology
    • Autoimmune Diseases
    • Computational Biology

    Background:

    • Sjögren's syndrome (SjD) is a chronic autoimmune disorder affecting moisture-producing glands.
    • The human leukocyte antigen (HLA) class II molecule HLA-DR3 is strongly associated with SjD.
    • Post-translational modifications (PTMs) may influence the presentation of SjD autoantigens.

    Purpose of the Study:

    • To investigate how PTMs affect the binding of SjD-associated autoantigens to HLA-DR3.
    • To analyze the impact of PTM-mimic peptides on autoantigen presentation and T cell responses.

    Main Methods:

    • Computational framework to analyze PTM-mimic peptide binding to HLA-DR3.
    • Analysis of full-length SjD autoantigen sequences (Ro60, Ro52, La) for PTM-eligible sites.
    • Experimental validation of PTM-mimic peptides and T cell responses.
    • Structural modeling of peptide-DR3 complexes.

    Main Results:

    • PTM substitutions at anchor positions generally reduced predicted binding affinity.
    • Specific regions in Ro60, Ro52, and La autoantigens showed high densities of PTM-eligible sites.
    • Experimental validation revealed enhanced T cell responses with PTM-mimic peptides, linked to increased HLA-DR3 binding.
    • Structural modeling indicated altered peptide-DR3 interactions due to PTM mimics.

    Conclusions:

    • PTMs can influence autoantigen presentation to T cells in an HLA-DR3-dependent manner.
    • PTM-mimic peptides may alter the immunogenicity of SjD autoantigens.
    • Findings offer insights into SjD pathogenesis and potential therapeutic strategies targeting T cell responses.