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Related Experiment Video

Updated: Jan 13, 2026

Passaging Human Neural Stem Cells
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UC Irvine's Brain Initiative Cell Atlas Network (BICAN) Brain Procurement Program for the Center for Multiomic Human

Jillian V Berry1, Bryan M Tran1, Ginny Wu2

  • 1Department of Pathology and Laboratory Medicine, University of California, Irvine.

Biorxiv : the Preprint Server for Biology
|January 9, 2026
PubMed

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Summary
This summary is machine-generated.

Establishing a neurotypical human brain procurement program provides a scalable model for brain cell atlas research. This initiative highlights challenges and opportunities in donor recruitment for population-reflective studies.

Area of Science:

  • Neuroscience
  • Human Brain Tissue Procurement
  • Cellular Atlasing

Background:

  • High-quality neurotypical postmortem human brain tissue is crucial for creating comprehensive human brain cell atlases.
  • Acquiring such tissue presents significant challenges, impacting research progress.

Purpose of the Study:

  • To establish and describe the UC Irvine's Brain Procurement Program for collecting neurotypical donor brains.
  • To support multiomic mapping studies within the NIH BRAIN Initiative Cell Atlas Network (BICAN).

Main Methods:

  • Developed standardized workflows for donor identification, brain recovery, processing, and dissection.
  • Formed multi-institutional partnerships, including with the Orange County Coroner's Office.
  • Implemented rigorous neurotypical donor selection and data management protocols.
Keywords:
BICANbrain collection and processingbrain donationhuman brain bankingneurotypicalpopulation-reflective representation

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Last Updated: Jan 13, 2026

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Main Results:

  • Demonstrated the feasibility of a community-based, multi-institutional framework for brain tissue procurement.
  • Identified challenges in recruiting neurotypical donors and ensuring demographic representation.
  • Highlighted opportunities to enhance outreach and donation pathways.

Conclusions:

  • The established program offers a scalable model for advancing population-reflective human brain cell atlas efforts.
  • Addressing recruitment barriers is key to improving demographic diversity in brain tissue donation.
  • This initiative facilitates critical research for understanding the human brain.