Related Experiment Video
Updated: Jan 13, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Tetrahydropyridines: a recent update for their multicomponent synthesis
Md Musawwer Khan1, Faiz Ahmad Faiz1, Mohd Sufiyan Khan1
1Department of Chemistry, Aligarh Muslim University Aligarh-202002 India musawwer@gmail.com.
Abstract:
Tetrahydropyridines (THPs) are important nitrogen-based ring compounds found in many natural and synthetic molecules with wide biological importance. Their simple structure and chemical flexibility make them valuable in drug design and organic synthesis. Among different synthetic methods, multicomponent reactions (MCRs) have become a fast, efficient, and eco-friendly approach for preparing a large variety of THP derivatives in a single step. This review focuses on recent developments in the synthesis of tetrahydropyridines using MCRs with different nitrogen sources such as amines, enamines, imines, ammonia, ammonium acetate, etc. It also highlights green and sustainable methods like solvent-free, microwave-assisted, photoinduced, and catalyst-free reactions. Overall, this review explains how multicomponent reactions provide an easy, economical, and environmentally friendly route for building diverse tetrahydropyridine structures useful in chemical and medicinal research.
More Related Videos
Related Concept Videos
Aromatic Hydrocarbon Cations: Structural Overview
Removing one hydrogen from the intervening CH2 group...
Five-Membered Heterocyclic Aromatic Compounds: Overview
Thermal and Photochemical Electrocyclic Reactions: Overview
Woodward–Hoffmann Selection Rules and Microscopic Reversibility
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Cycloaddition Reactions: Overview

