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Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
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Assessment of Bone Fracture Healing Using Micro-Computed Tomography
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Correlation between Biochemical Parameters and Radiographic Healing Score in Tibial Fractures.

Abhinav Sharma1, Madhur Gupta2, Vipin Kumar Mishra1

  • 1Department of Orthopaedics, Government Medical College, Satna, Madhya Pradesh, India.

Journal of Orthopaedic Case Reports
|January 9, 2026
PubMed
Summary
This summary is machine-generated.

Biochemical markers like alkaline phosphatase (ALP) and Vitamin D correlate with tibial fracture healing. Monitoring these markers alongside X-rays can help assess fracture repair potential.

Keywords:
Tibial fractureVitamin Dalkaline phosphatasebone healingradiographic union score

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Area of Science:

  • Orthopedics
  • Biochemistry
  • Radiology

Background:

  • Fracture healing is a complex biological process.
  • Systemic biochemical factors influence bone formation and remodeling.
  • Understanding these factors can improve fracture repair prediction.

Purpose of the Study:

  • To evaluate the association between serum biochemical markers and radiographic evidence of tibial fracture union.
  • To enhance the understanding of fracture repair mechanisms.

Main Methods:

  • Prospective observational study of 63 adult patients with tibial shaft fractures.
  • Serial measurements of serum calcium, phosphorus, alkaline phosphatase (ALP), Vitamin D, and parathyroid hormone (PTH).
  • Radiographic healing assessed using the Radiographic Union Score for Tibial fractures (RUST).

Main Results:

  • Serum ALP, Vitamin D, phosphorus, and calcium levels increased during healing, while PTH decreased.
  • Radiographic Union Score for Tibial fractures (RUST) scores increased progressively.
  • Alkaline phosphatase (ALP) showed the strongest positive correlation with RUST scores (r = 0.61, P < 0.001).

Conclusions:

  • Serum biochemical markers, especially ALP and Vitamin D, reflect fracture healing progression.
  • These markers significantly correlate with radiographic union.
  • Biochemical monitoring aids in assessing tibial fracture healing potential.