Bioactive glass-based core-shell nanoparticles: Multifunctional platforms for controlled drug release and biomedical...

Area of Science:

• Biomaterials Science
• Nanotechnology
• Materials Chemistry

Background:

• Core-shell nanoparticles are multifunctional platforms for precise control in biomedical applications.
• Bioactive glasses offer advantages over silica due to bioactivity and therapeutic ion release.

Purpose of the Study:

• To comprehensively review core-shell nanostructures with bioactive glass cores.
• To analyze shell materials for controlled release and biological performance.

Main Methods:

• Discussed composition and synthesis of bioactive glass nanoparticles.
• Evaluated inorganic and polymeric shell materials for physicochemical roles.
• Explored challenges and future directions for clinical implementation.

Main Results:

• Shell materials modulate drug diffusion, stability, degradation, and targeting.
• Bioactive glass core-shell structures offer tunable properties for tailored therapies.
• Inorganic, natural, and synthetic polymeric shells provide versatile engineering options.

Conclusions:

• Core-shell bioactive glass nanoparticles represent a customizable strategy for advanced biomedical therapies.
• Surface engineering integrates structural functionalities for next-generation treatments.
• Addressing challenges in in vivo assays and clinical translation is crucial for implementation.