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Folate deficiency during intravenous hyperalimentation.

P C Shah, M Zafar, A R Patel

    Journal of Medicine
    |January 1, 1977
    PubMed
    Summary
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    Chronic alcoholism and intravenous feeding can lead to folate deficiency, causing pancytopenia. Folic acid supplementation is crucial for hematologic recovery in these surgical patients.

    Area of Science:

    • Clinical Nutrition
    • Hematology

    Background:

    • Hyperalimentation therapy is used for patients with complex surgical issues.
    • Alcoholism is associated with poor nutritional status and folate deficiency.

    Observation:

    • Two alcoholic patients receiving intravenous hyperalimentation developed folate deficiency.
    • One patient presented with severe pancytopenia after prolonged intravenous feeding.

    Findings:

    • Folate deficiency was identified at 10 and 2 weeks in the two patients.
    • Folic acid treatment led to complete hematologic recovery in both individuals.
    • Factors contributing to deficiency include poor folate stores, inadequate intake, infection, gastric suction, and folate-deficient IV fluids.

    Implications:

    Related Experiment Videos

    • Highlights the risk of folate deficiency in alcoholic patients undergoing hyperalimentation.
    • Suggests the need for routine folate monitoring and supplementation in this patient group.
    • Emphasizes the importance of considering nutritional status in surgical patient management.