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Updated: Jan 13, 2026

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance
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ARHGEF2 Isoform Switching Couples Intestinal Epithelial Barrier Function with Autophagic Response to Pathogens

Hans-Christian Reinecker1, Shuyuan Chen1, Alka Diwaker1

  • 1Department of Medicine, Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, 5959 Harry Hines Boulevard, Dallas, Texas 75390, United States.

Research Square
|January 9, 2026
PubMed
Summary

Epithelial cells use specific GEF-H1 isoforms to maintain gut barrier integrity and activate autophagy against pathogens. An isoform switch disrupts this defense, causing inflammation and loss of polarity.

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