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Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
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Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...

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Related Experiment Video

Updated: May 24, 2026

Meal Duration as a Measure of Orofacial Nociceptive Responses in Rodents
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Dexketoprofen Time-Dependent Administration After Third Molar Extraction: A Pilot Randomized Cross-Over Controlled

Fabián Pérez-González1, Mohammad Abusamak2, Leire Virto Ruiz1,3

  • 1Faculty of Dentistry, Department of Dental Clinical Specialties, University Complutense of Madrid, Madrid, Spain.

Clinical and Experimental Dental Research
|January 9, 2026
PubMed
Summary
This summary is machine-generated.

Daytime administration of Dexketoprofen may be sufficient for managing pain after third molar extraction. This chronotherapy approach showed faster pain recovery and fewer complications, suggesting optimized anti-inflammatory treatment.

Keywords:
NSAIDs, postoperative complications, third molar extractionchronotherapycytokines

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Area of Science:

  • Oral and Maxillofacial Surgery
  • Pharmacology
  • Immunology

Background:

  • Bilateral third molar extraction is a common surgical procedure.
  • Postoperative pain and swelling are significant concerns for patients.
  • Optimizing anti-inflammatory drug administration can improve patient recovery.

Purpose of the Study:

  • To evaluate the impact of chronotherapy on recovery after bilateral third molar extraction.
  • To assess the efficacy of daytime Dexketoprofen administration compared to standard dosing.
  • To analyze the influence of chronotherapy on pain, swelling, and inflammatory markers.

Main Methods:

  • A randomized cross-over controlled trial involving 10 patients.
  • Chronotherapy group received daytime Dexketoprofen (25 mg); control group received standard 12-hourly dosing.
  • Pain, swelling, mouth opening, and inflammatory markers (IL-1β, IL-1a, IL-2, IL-4, IL-6, IL-7, IL-10, IL-13) were measured postoperatively.

Main Results:

  • No significant differences in pain, swelling, or trismus between groups.
  • The chronotherapy group exhibited faster pain intensity reduction and fewer overall complications.
  • No statistical differences were found in inflammatory markers between the groups at 72 hours or 7 days.

Conclusions:

  • Daytime administration of NSAIDs (non-steroidal anti-inflammatory drugs) may be adequate for postoperative pain management after third molar extraction.
  • Chronotherapy with Dexketoprofen demonstrated potential benefits in faster recovery and reduced complications.
  • Further research may explore optimal chronotherapeutic strategies for oral surgery recovery.