Dexketoprofen Time-Dependent Administration After Third Molar Extraction: A Pilot Randomized Cross-Over Controlled...

Area of Science:

• Oral and Maxillofacial Surgery
• Pharmacology
• Immunology

Background:

• Bilateral third molar extraction is a common surgical procedure.
• Postoperative pain and swelling are significant concerns for patients.
• Optimizing anti-inflammatory drug administration can improve patient recovery.

Purpose of the Study:

• To evaluate the impact of chronotherapy on recovery after bilateral third molar extraction.
• To assess the efficacy of daytime Dexketoprofen administration compared to standard dosing.
• To analyze the influence of chronotherapy on pain, swelling, and inflammatory markers.

Main Methods:

• A randomized cross-over controlled trial involving 10 patients.
• Chronotherapy group received daytime Dexketoprofen (25 mg); control group received standard 12-hourly dosing.
• Pain, swelling, mouth opening, and inflammatory markers (IL-1β, IL-1a, IL-2, IL-4, IL-6, IL-7, IL-10, IL-13) were measured postoperatively.

Main Results:

• No significant differences in pain, swelling, or trismus between groups.
• The chronotherapy group exhibited faster pain intensity reduction and fewer overall complications.
• No statistical differences were found in inflammatory markers between the groups at 72 hours or 7 days.

Conclusions:

• Daytime administration of NSAIDs (non-steroidal anti-inflammatory drugs) may be adequate for postoperative pain management after third molar extraction.
• Chronotherapy with Dexketoprofen demonstrated potential benefits in faster recovery and reduced complications.
• Further research may explore optimal chronotherapeutic strategies for oral surgery recovery.