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Related Concept Videos

Brain Imaging01:14

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Longitudinal Associations Between Physical Activity Behavior and Structural Brain MRI Features After Stroke: A

Geske Luzum1, Eva B Aamodt2, Heather Allore3

  • 1Department of Neuromedicine and Movement Science, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.

Neurorehabilitation and Neural Repair
|January 9, 2026
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Summary
This summary is machine-generated.

Higher physical activity (PA) after stroke is linked to larger brain volumes and a younger brain age. Maintaining an active lifestyle post-stroke benefits brain structure and may slow brain aging.

Keywords:
brain agebrain maintenanceneuroimagingphysical activitysecondary prevention

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Area of Science:

  • Neuroscience
  • Radiology
  • Public Health

Background:

  • Post-stroke physical activity (PA) may influence brain structure and brain age.
  • Inter-individual differences in brain volumes and age estimates after stroke are not fully understood.

Purpose of the Study:

  • To examine the longitudinal relationship between post-stroke physical activity and structural brain MRI features.
  • To investigate how PA levels and trajectories affect brain age gap and brain volumes.

Main Methods:

  • Longitudinal cohort study using accelerometer data for PA assessment.
  • Linear mixed models analyzed associations between daily steps, PA trajectories, brain age gap (BAG), and brain volumes (cortical, hippocampal, thalamic).
  • Models controlled for age, sex, education, stroke severity, and intracranial volume.

Main Results:

  • Increased daily steps correlated with a lower BAG and larger cortical and hippocampal volumes.
  • The association between daily steps and thalamic volume showed a curvilinear pattern, peaking at approximately 4700 steps/day.
  • Participants in the highest PA trajectory group exhibited significantly lower BAG and larger thalamic volumes compared to the least active group.

Conclusions:

  • Higher levels of physical activity post-stroke are associated with beneficial structural brain changes.
  • Maintaining physical activity may contribute to a younger brain appearance and preserve brain volume after stroke.