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Prescribing Patterns of Gabapentinoids in Patients with Chronic Obstructive Pulmonary Disorder
Mollie Vergara1, Mate Michael Soric1, Olivia King2
1Department of Pharmacy Practice, Northeast Ohio Medical University College of Pharmacy, Rootstown, Ohio, USA.
COPD
|January 9, 2026
Summary
Gabapentinoid prescribing is common in patients with chronic obstructive pulmonary disorder (COPD), increasing risks of respiratory depression. More provider education is needed on these dangerous drug interactions.
Area of Science:
- Pharmacology
- Pulmonology
- Public Health
Background:
- The U.S. Food and Drug Administration (FDA) warned about serious respiratory depression risks with gabapentinoids in patients with respiratory risk factors, including chronic obstructive pulmonary disorder (COPD).
- Gabapentinoid prescriptions are increasing, raising concerns about their use in vulnerable patient populations like those with COPD.
Purpose of the Study:
- To assess the prevalence and predictors of gabapentinoid prescribing in patients diagnosed with COPD.
- To identify patient characteristics associated with increased risk of receiving gabapentinoids among those with COPD.
Main Methods:
- Analysis of data from the National Ambulatory Medical Care Survey (NAMCS) between 2013-2018 (excluding 2017).
- Examined 1,131 unweighted office visits, representing approximately 53.6 million nationally.
Main Results:
- Gabapentinoids were prescribed in 10.8% of COPD patient visits (146 out of 1,131), translating to over a million annual office visits.
- Predictors for gabapentinoid use in COPD patients included concurrent diabetes mellitus, opioid use, and current tobacco use.
Conclusions:
- Gabapentinoid prescribing in patients with COPD is prevalent and associated with increased respiratory depression risks.
- Enhanced provider education is crucial to mitigate risks of concomitant COPD and gabapentinoid use, emphasizing caution in prescribing.
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