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Updated: Jan 13, 2026

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A Population-Centered Health Framework for Analyzing Superfund Sites With a History of Volatile Organic Compound
Samantha Satterly1, Caison Black1, Rochelle H Holm1
1Center for Healthy Air Water and Soil, Christina Lee Brown Envirome Institute, School of Medicine, University of Louisville, Louisville, KY, USA.
None:
BackgroundAirborne toxicants such as volatile organic compounds (VOCs) increase the risk of inducing or exacerbating cardiometabolic disease. The Environmental Protection Agency prioritizes Superfund sites based on the level of contamination and the likelihood that a site poses a threat to human health or the environment.PurposeThis paper proposes an alternative approach to prioritizing Superfund sites with VOC contamination by focusing on the size and health status of nearby populations.Research DesignAs a case study, we examine relevant data sources and assess how they characterize place-based cardiovascular health risk and disease burden among populations residing near Superfund sites in Kentucky.Results and ConclusionOur findings suggest an approach to more effectively protect public health in areas where VOC exposure may amplify existing cardiometabolic risks, thereby guiding state and local governments in decisions regarding site remediation and healthcare resource allocation.
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