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Adult-Onset Subacute Sclerosing Panencephalitis Presenting With Subacute Cognitive Deficits

Dennis Yeow1,2,3, Nicola McKern3,4, Vincent Oxenham3,4

  • 1Neurodegenerative Service, Prince of Wales Hospital and Neuroscience Research Australia, Sydney, New South Wales, Australia.

Annals of Clinical and Translational Neurology
|January 9, 2026
PubMed

Insights

Subacute sclerosing panencephalitis (SSPE) in adults can present with cognitive decline and frontoparietal dysfunction. Early neuropsychological assessment may aid in diagnosing this rare measles complication.

Area of Science:

  • Neurology
  • Neuroimmunology
  • Viral Encephalitis

Background:

  • Subacute sclerosing panencephalitis (SSPE) is a rare, progressive neurological disorder.
  • Typically associated with measles infection in childhood, adult-onset SSPE is exceptionally uncommon.
  • Early diagnosis is challenging due to nonspecific initial symptoms.
Keywords:
SSPEadult‐onsetcognitive deficitmyoclonus

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