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  1. Home
  3. Ros-responsive Hybrid Nanoparticles Enable Dual-target Neurovascular Repair Via Blood-brain Barrier-on-chip Validation.
  1. Home
  3. Ros-responsive Hybrid Nanoparticles Enable Dual-target Neurovascular Repair Via Blood-brain Barrier-on-chip Validation.

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ROS-Responsive Hybrid Nanoparticles Enable Dual-Target Neurovascular Repair via Blood-Brain Barrier-on-Chip

Shanglin Cai1, Wangyu Bi1, Liang Li1

  • 1School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, China.

Small (Weinheim an Der Bergstrasse, Germany)
|January 9, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

This study introduces novel hybrid nanoparticles for dual-target gene therapy, effectively treating blood-brain barrier leakage and neuronal damage in neurovascular diseases. The innovative approach enhances neurovascular repair and offers a new paradigm for disease intervention.

Keywords:
ROS‐responsive nanoparticlesblood brain‐barrier‐on‐chipdual‐target gene therapyneurovascular diseaseneurovascular repair

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Nanotechnology

Background:

  • Blood-brain barrier (BBB) leakage and neuronal damage are key features of neurovascular diseases.
  • Current therapies struggle to address both BBB integrity and neuronal health simultaneously.
  • Limitations in in vitro BBB models hinder the translation of neurotherapeutics.

Purpose of the Study:

  • To develop a dual-target gene therapy using novel hybrid nanoparticles.
  • To mitigate neuronal oxidative stress and BBB pyroptosis concurrently.
  • To create a predictive microfluidic BBB-on-chip platform for neurovascular disease modeling.

Main Methods:

  • Design of reactive oxygen species-responsive exosome-liposome hybrid nanoparticles for co-delivery of siBACH1 and siGSDMD.
  • Development of a microfluidic BBB-on-chip platform mimicking MPTP-induced neurovascular disease pathology.
  • In vitro and in vivo evaluation of the hybrid nanoparticles' efficacy.

    • Main Results:

    • The hybrid nanoparticles effectively delivered siRNAs to target oxidative stress and pyroptosis.
    • The BBB-on-chip platform accurately recapitulated disease hallmarks.
    • Both in vitro and in vivo studies confirmed synergistic restoration of BBB integrity and neuronal function.

    Conclusions:

    • The developed hybrid nanoparticles offer a dual-target gene therapy for synergistic neurovascular repair.
    • The BBB-on-chip platform provides a predictive model for neurotherapeutic development.
    • This integrated approach establishes a new paradigm for precision intervention in neurovascular diseases.