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Updated: Jun 29, 2026

Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor
Published on: January 4, 2016
A conformation-dependent bifunctional fluorescent sensor for viscosity-pH monitoring in oxidative stress models
Lifang Guo1, Yuxi Ding1, Haijiao Wu1
1Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, China. guolf@ecust.edu.cn.
Abstract:
A conformation-dependent bifunctional sensor is developed by capitalizing on a vibration-induced emission chromophore for viscosity sensing and an acid-triggered oxazolidine switch for pH sensing. This design yields a large Stokes shift (>150 nm), enabling dual-channel and crosstalk-free monitoring of viscosity and pH in oxidative stress models.
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