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Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats
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Cephalosporin-induced hemolytic anemia: a case study.

Graça Almeida1, Ana Costa2, Eugénia Vasconcelos3

  • 11Reference Laboratory of Immunohematology, Portuguese Institute of Blood and Transplantation, IPST, IP, Lisbon, Portugal.

Immunohematology
|January 9, 2026
PubMed
Summary

This case report identifies cefuroxime and ceftriaxone as causes of drug-induced immune hemolytic anemia (DIIHA) in a child. Early diagnostic testing is crucial for identifying DIIHA, even with prior antibiotic tolerance.

Area of Science:

  • Hematology
  • Immunology
  • Pediatrics

Background:

Keywords:
DIIHAceftriaxonecefuroximedrug-dependent antibodiesimmune hemolytic anemia

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  • Drug-induced immune hemolytic anemia (DIIHA) is a rare but severe condition, frequently observed in children receiving cephalosporins.
  • A 10-year-old girl experienced severe hemolysis, hypovolemic shock, and renal dysfunction after cefuroxime and ceftriaxone administration.
  • Previous tolerance to ceftriaxone did not prevent the adverse reaction in this patient.