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Updated: Jan 13, 2026
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In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System
Published on: January 9, 2020
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Genomic Aberrations of Antisense Gene Transcripts in Head and Neck Cancer
Jishi Ye1, Stacy Magdalene Abbang2, Yuen-Keng Ng3,4
1Department of Pain Management, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Cells
|January 9, 2026
Summary
Antisense genes are crucial in head and neck cancer (HNC). Four specific antisense genes show clinical validation, highlighting their potential as biomarkers for HNC patient outcomes and guiding future research.
Area of Science:
- Genomics
- Molecular Biology
- Cancer Research
Background:
- Antisense genes (AS), a type of long non-coding RNA (lncRNA), are transcribed from the opposite strand of human genes.
- Dysregulated expression and genomic aberrations of AS genes are implicated in various cancers, including head and neck cancer (HNC).
- A comprehensive review of HNC-associated AS genes is needed for biomarker and drug development.
Purpose of the Study:
- To conduct a comprehensive review of genomic aberrations in antisense genes associated with HNC.
- To evaluate the clinical significance of these aberrations in relation to HNC patient prognosis, disease progression, and treatment response.
- To identify promising antisense genes for clinical biomarker development in HNC.
Main Methods:
- Systematic review of literature on genomic aberrations (mutations, copy number changes, RNA expression, SNPs) of antisense genes in HNC.
- Analysis of associations between genomic aberrations and HNC patient outcomes, including prognosis, progression, and therapy resistance.
- Cross-validation of identified antisense genes across multiple independent cohorts and research studies.
Main Results:
- Only 2.3% (52/2236) of known human antisense genes have been investigated in HNC.
- Genomic aberrations in AS genes impact HNC prognosis, progression, cell signaling, and drug/radiation resistance.
- Four antisense genes—HOXA10-AS, LEF1-AS1, MSC-AS1, and ZEB2-AS1—were clinically cross-validated and consistently linked to patient outcomes in HNC.
Conclusions:
- HOXA10-AS, LEF1-AS1, MSC-AS1, and ZEB2-AS1 are prioritized candidates for clinical biomarker development in HNC.
- Further validation of single nucleotide polymorphisms (SNPs) in AS genes across diverse ethnic groups is recommended for global HNC applications.
- This review underscores the clinical relevance of antisense genes in HNC and their potential for advancing precision medicine.
Keywords:
antisense genesbiomarkersdrug sensitivityfunctional roleshead and neck cancer (HNC)signaling regulationMore Related Videos
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