Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

2.7K
Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
2.7K
Hormones Regulating Blood Glucose01:16

Hormones Regulating Blood Glucose

6.4K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
6.4K
Liver Physiology01:30

Liver Physiology

3.5K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.5K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.2K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.2K
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

2.2K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
2.2K
Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

836
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
836

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex-Specific Cytokine Responses and Metabolic Adaptation to Weight Loss in Obesity with Insulin Resistance.

Nutrients·2026
Same author

Body mass index as a key determinant of oxidative stress in women undergoing infertility treatment.

Frontiers in reproductive health·2026
Same author

A metabolic perspective on microglia in Alzheimer's disease.

Neural regeneration research·2026
Same author

Malnutrition Is Associated with Increased Liver Stiffness in Type 2 Diabetes: The Mediating Role of Inflammation.

Biomolecules·2025
Same author

Emerging Frontiers in Neuro-Oncology: Insights into Extracellular Vesicle-Driven Tumor Mechanisms and Nanotherapeutic Strategies.

International journal of molecular sciences·2025
Same author

Respiratory Function and Oxidative Stress in Smoking Zinc Smelter Workers Exposed to Lead.

Journal of clinical medicine·2025

Related Experiment Video

Updated: Jan 13, 2026

Precise Visualization of Insulin Receptors A and B in Murine Brain with an RNA In Situ Hybridization Assay
08:34

Precise Visualization of Insulin Receptors A and B in Murine Brain with an RNA In Situ Hybridization Assay

Published on: July 15, 2025

645

Insulin Growth Factor Binding Protein-6 and the Liver.

Anna Rita Daniela Coda1, Sławomir Kasperczyk2, Michał Dobrakowski3

  • 1C.R.E.A.T.E.-Center for Research and Innovation in Medicine, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.

Cells
|January 9, 2026
PubMed
Summary

Insulin-like growth factor-binding protein 6 (IGFBP-6) plays a complex role in liver health and disease. This review highlights its impact on liver metabolism, injury, and cancer, suggesting its potential as a diagnostic and therapeutic target.

Keywords:
IGF-1R signalingIGF-IIIGFBP-6cholangiocarcinomahepatic stellate cellshepatocellular carcinomaliver fibrosislobular zonationpost-translational modificationspatial transcriptomics

More Related Videos

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
08:04

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method

Published on: October 23, 2018

19.7K
A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
09:35

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

Published on: July 16, 2016

11.6K

Related Experiment Videos

Last Updated: Jan 13, 2026

Precise Visualization of Insulin Receptors A and B in Murine Brain with an RNA In Situ Hybridization Assay
08:34

Precise Visualization of Insulin Receptors A and B in Murine Brain with an RNA In Situ Hybridization Assay

Published on: July 15, 2025

645
Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
08:04

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method

Published on: October 23, 2018

19.7K
A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
09:35

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

Published on: July 16, 2016

11.6K

Area of Science:

  • Liver biology and disease
  • Endocrinology
  • Molecular signaling

Background:

  • The insulin-like growth factor (IGF) axis is crucial for liver function, but individual IGF-binding proteins (IGFBPs) roles are unclear.
  • IGFBP-6, an IGF-II-preferring binding protein, influences IGF bioavailability and signaling, with independent actions.

Purpose of the Study:

  • To synthesize current evidence on IGFBP-6 in liver biology and disease.
  • To evaluate its roles in hepatic development, homeostasis, injury, and cancer.
  • To assess its translational potential for diagnosis and therapy.

Main Methods:

  • Review of experimental and clinical data on IGFBP-6 expression, regulation, and function.
  • Analysis of IGFBP-6 involvement in canonical IGF signaling pathways (PI3K-AKT, RAS-MAPK).
  • Examination of IGFBP-6 links to liver conditions like steatosis, inflammation, fibrosis, and cancers (HCC, cholangiocarcinoma).

Main Results:

  • IGFBP-6 expression and processing vary with liver development, homeostasis, and injury.
  • It modulates IGF-II/IGF1R signaling and downstream pathways.
  • IGFBP-6 is implicated in steatosis, inflammation, fibrogenesis, and liver cancers, showing both tumor-suppressive and pro-migratory effects.
  • Potential crosstalk with hypoxia, Wnt/β-catenin, TGF-β signaling, and the immune microenvironment.

Conclusions:

  • IGFBP-6 is a nuanced regulator of liver pathophysiology.
  • It holds promise as a biomarker for patient stratification and therapeutic targeting.
  • Further research is needed for standardized measurement, cell-type-resolved profiling, and in vivo studies.