Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Synaptic Plasticity-Intrinsic Excitability and Antidepressant Discovery.

Biomedicines·2026

Same author

From Polyphenols to Prodrugs: Bridging the Blood-Brain Barrier with Nanomedicine and Neurotherapeutics.

International journal of molecular sciences·2026

Same author

Receptor-Mitochondria Crosstalk in the Kynurenine Metabolic Pathway: Integrating Metabolomics and Clinical Mass Spectrometry.

Antioxidants (Basel, Switzerland)·2026

Same author

From Monoamines to Systems Psychiatry: Rewiring Depression Science and Care (1960s-2025).

Biomedicines·2026

Same author

Screen, Sample, Stratify: Biomarkers and Machine Learning Compress Dementia Pathways.

Biomedicines·2026

Same author

Harnessing Dietary Tryptophan: Bridging the Gap Between Neurobiology and Psychiatry in Depression Management.

International journal of molecular sciences·2026

Search research articles

Related Experiment Video

Updated: Jan 13, 2026

Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions

Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions

Published on: July 26, 2024

Neurogenesis and Neuroinflammation in Dialogue: Mapping Gaps, Modulating Microglia, Rewiring Aging.

Masaru Tanaka¹

¹Danube Neuroscience Research Laboratory, HUN-REN-SZTE Neuroscience Research Group, Hungarian Research Network, University of Szeged, Tisza Lajos krt. 113, H-6725 Szeged, Hungary.

|January 9, 2026

Summary

Aging brains face declining neurogenesis and rising neuroinflammation, termed inflammaging. Strategies like immunomodulation and epigenetic editing can restore cognitive function by reprogramming this interaction.

Keywords:

Alzheimer disease aging brain cognitive decline epigenetics hippocampus inflammasomes microglia neurogenesis neuroinflammation translational research

More Related Videos

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

Published on: May 11, 2015

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Published on: October 27, 2019

Related Experiment Videos

Last Updated: Jan 13, 2026

Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions

Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions

Published on: July 26, 2024

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

Published on: May 11, 2015

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Published on: October 27, 2019

Area of Science:

Neuroscience
Immunology
Aging Research

Background:

Aging brains exhibit declining neurogenesis and increasing neuroinflammation, a process known as inflammaging.
This convergence impairs synaptic plasticity and cognitive function due to maladaptive glial states.
Critical knowledge gaps exist in microglial heterogeneity, epigenetic mechanisms, and immune responses within the brain niche.

Purpose of the Study:

To address knowledge gaps in the aging brain's neurogenesis and neuroinflammation dialogue.
To evaluate strategies for reprogramming the interaction between neurogenesis and neuroinflammation.
To provide a roadmap for delaying cognitive decline through mechanistic precision.

Main Methods:

Review of current literature on neurogenesis and neuroinflammation in aging.
Identification of five major knowledge gaps in the field.
Evaluation of strategies including longitudinal imaging, immunomodulation, glial reprogramming, inflammasome inhibitors, and epigenetic editing.

Main Results:

Neurogenesis potential can be preserved or restored in aging brains.
Tuning the immune and epigenetic environments is key to maintaining cognitive function.
Mechanistic precision in interventions can guide clinical innovation for neurodegenerative diseases.

Conclusions:

Neurogenic potential is not lost with age but can be modulated by immune and epigenetic factors.
A roadmap is proposed for reshaping the aging brain's trajectory and delaying cognitive decline.
Integrating cellular plasticity with immune modulation offers a path to re-engineer resilience across the lifespan.