The role of systemic inflammation in patients with conjunctivochalasis

To compare systemic inflammation parameters and blood lipid profile in patients with conjunctivochalasis versus healthy individuals.

Thirty patients with conjunctivochalasis(Cch) and thirty age-matched healthy controls were included in this retrospective study. Complete blood count (CBC) parameters and serum levels of total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TG) were obtained from electronic medical records. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and monocyte-to-HDL ratio (MHR) were calculated for each participant. Group differences were analyzed statistically.

The monocyte-to-HDL ratio was significantly higher in the conjunctivochalasis group (p = 0.023), while hemoglobin levels were significantly lower (p = 0.001). No additional significant differences were observed in other hematological or lipid parameters.

This study is the first to demonstrate an elevated monocyte-to-HDL ratio in patients with conjunctivochalasis. The concurrent reduction in hemoglobin levels provides further support for a potential systemic association. These findings suggest that conjunctivochalasis may involve not only localized ocular changes but also systemic inflammatory processes.