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Updated: Jan 13, 2026

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
10:09

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Published on: January 7, 2019

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KIF14 in cancer biology: implications for diagnosis and therapy

Ashok Kumar Bishoyi1, Shaker Al-Hasnaawei2,3, Subbulakshmi Ganesan4

  • 1Department of Microbiology, Faculty of Science, Marwadi University Research Center, Marwadi University, Rajkot, Gujarat, India. ashokkumarbishoyi2@gmail.com.

Clinical & Experimental Metastasis
|January 9, 2026
PubMed

Insights

Kinesin family member 14 (KIF14) is overexpressed in many cancers, driving tumor growth and resistance to therapy. Targeting KIF14 offers a promising strategy for treating aggressive and hard-to-treat malignancies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Kinesin family member 14 (KIF14) is a motor protein vital for cell division and intracellular transport.
  • KIF14 overexpression is linked to poor prognosis and therapy resistance in multiple cancers.
  • Its specific roles in cancer progression require comprehensive analysis.

Purpose of the Study:

  • To review the involvement of KIF14 in cancer progression.
  • To explore the molecular mechanisms of KIF14's tumorigenic effects.
  • To evaluate KIF14 as a prognostic biomarker and therapeutic target.

Main Methods:

  • Comprehensive literature review of oncological studies on KIF14.
  • Analysis of KIF14's role in cell cycle regulation and mitotic spindle formation.
  • Exploration of KIF14's involvement in oncogenic signaling pathways.

Main Results:

  • KIF14 overexpression is a common feature in breast, ovarian, lung, liver, and brain cancers.
  • KIF14 contributes to tumor aggressiveness, poor clinical outcomes, and therapeutic resistance.
  • Its functions are implicated in cell cycle dysregulation and aberrant mitotic spindle assembly.

Conclusions:

  • KIF14 is a significant driver of tumor growth and metastasis.
  • KIF14 holds potential as a prognostic biomarker for cancer patients.
  • Targeting KIF14 presents a promising therapeutic avenue for aggressive cancers.
Keywords:
CancerKIF14Kinesin superfamilyMotor proteinsOncogene

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