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Genome-Wide Association and Transcriptome Analyses Identify OsCBP606 as a Calmodulin-Mediated Susceptibility Gene to
Zhikai Han1,2, Wenyu Lu1,2, Shengyi Chen1,2
1National Plant Space Breeding Engineering Technology Research Center, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Rice (New York, N.Y.)
|January 9, 2026
Summary
Researchers identified seven quantitative trait loci (QTLs) for rice blast resistance using genome-wide association studies. The gene OsCBP606 was identified as a key regulator of rice immunity against Magnaporthe oryzae.
Area of Science:
- Plant Pathology
- Genetics
- Molecular Biology
Background:
- Rice blast, caused by Magnaporthe oryzae, significantly impacts global rice production.
- Developing resistant rice varieties is essential for food security.
Purpose of the Study:
- To identify quantitative trait loci (QTLs) and candidate genes for rice blast resistance.
- To understand the genetic basis of resistance to Magnaporthe oryzae.
Main Methods:
- Genome-wide association study (GWAS) using phenotypic and genotypic data from 236 rice accessions.
- Differential gene expression analysis and gene annotation.
- Gene knockout and overexpression studies.
Main Results:
- Seven QTLs associated with rice blast resistance were identified on chromosomes 1, 5, 6, 7, 10, and 12.
- Four major QTLs (qMZ6.1, qMZ7.1, qMZ10.1, and qMZ12.1) were identified as key contributors.
- OsCBP606, encoding a calmodulin protein, was identified as the candidate gene for qMZ12.1.
- OsCBP606 knockout enhanced resistance, while overexpression increased susceptibility to Magnaporthe oryzae.
Conclusions:
- OsCBP606 plays a critical role in modulating rice immune responses against blast fungus.
- OsCBP606 is a promising target for breeding enhanced rice blast-resistant varieties.
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