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Updated: Jan 13, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

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Association of Thoracic Aortic Calcification with All-Cause Mortality in Maintenance Hemodialysis Patients: A

Xue-Mei Liu1,2, Yun Liu3, Li-Yan Liu2

  • 1Department of Nephrology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Institute of Nephrology, Jinan, 250014, China.

Current Medical Science
|January 9, 2026
PubMed

Insights

Calcification in the aortic arch (AAC) and descending thoracic aorta (DTAC) are significant predictors of mortality in patients undergoing maintenance hemodialysis (MHD). These findings highlight the prognostic value of thoracic aortic calcification in this high-risk population.

Area of Science:

  • Nephrology
  • Cardiology
  • Radiology

Background:

  • Cardiovascular disease (CVD) is the primary cause of death in end-stage renal disease (ESRD) patients on maintenance dialysis.
  • Understanding mortality predictors in this population is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate the prognostic significance of thoracic aortic calcification (TAC) in different segments for all-cause mortality.
  • To clarify the relationship between TAC and mortality in patients undergoing maintenance hemodialysis (MHD).

Main Methods:

  • Prospective study of stable adult MHD patients between July 2019 and December 2020.
  • Thoracic aortic calcification (TAC) assessed using chest X-rays or CT scans.
  • Cox proportional hazards models and Kaplan-Meier curves analyzed mortality risk factors.

Main Results:

  • Over a mean follow-up of 3.95 years, 18 out of 62 patients died.
  • Elevated systolic blood pressure, aortic arch calcification (AAC), and descending thoracic aortic calcification (DTAC) were independent risk factors for mortality.
  • Severe AAC or DTAC independently predicted death in MHD patients.

Conclusions:

  • Aortic arch calcification (AAC) and descending thoracic aortic calcification (DTAC) are significant predictors of all-cause mortality.
  • These findings underscore the importance of assessing TAC in MHD patients for risk stratification.
Abstract

Keywords:
Aortic arch calcificationCardiovascular diseaseMaintenance hemodialysisMortalityThoracic aortic calcification

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