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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
The Terpenoid Alkaloids of Colobognath Millipedes: Insights into Structural Diversity and Function
Arden Hatch1, Paul Marek2, Emily Mevers1
1Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States.
Abstract:
Colobognatha, a group of millipedes (Diplopoda) known for their unique biological traits (e.g., brood care and sociality), is the only group among millipedes to produce terpenoid alkaloids. Before 2020, only four terpenoid alkaloids had been identified; however, recent studies have resulted in a surge of new chemical discoveries and research into their ecological and biochemical roles. In this review, we outline the social characteristics of Colobognatha, the chemical investigations of their defensive secretions, and the bioactivity of the terpenoid alkaloids with a particular emphasis on new findings. We conclude by summarizing gaps in the research on these chemicals and provide insights into future research directions.
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Structural Isomerism
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...