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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Related Experiment Video

Updated: Jan 13, 2026

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Utility of RECELL for Traumatic Skin Defects: Protocol for a Prospective, Single-Arm Pilot Study.

Naoki Maegawa1, Hironobu Konishi1, Keisuke Masuda1

  • 1Department of Emergency and Critical Care Medicine, Nara Medical University, Shijyou-cho 840, Kashihara, 6348522, Japan, 81 744-22-3051 ext 3443, 81 744-22-5992.

JMIR Research Protocols
|January 9, 2026
PubMed
Summary
This summary is machine-generated.

This pilot study evaluates the RECELL skin reconstruction technique for traumatic skin defects. RECELL shows promise for wound closure and scar quality, with no adverse events reported in early trials.

Keywords:
autograftextremity traumaflap surgerynoncultured skin cell suspension techniqueopen fractureskin graftingsplit-thickness skin graftwound healing

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Area of Science:

  • Regenerative Medicine
  • Dermatology
  • Trauma Surgery

Background:

  • Split-thickness skin grafting is standard for traumatic skin defects but has limitations.
  • RECELL (a noncultured skin cell suspension technique) offers comparable outcomes to skin grafting for burns.
  • RECELL's application for severe traumatic skin defects is not yet widespread in Japan.

Purpose of the Study:

  • To evaluate the efficacy of the RECELL skin reconstruction technique combined with split-thickness mesh grafting for significant posttraumatic skin defects.
  • To assess wound closure and scar quality in patients undergoing RECELL-assisted skin reconstruction.
  • To validate the utility of RECELL in managing severe traumatic skin defects.

Main Methods:

  • A prospective, single-center, open-label pilot study enrolling patients aged 16+ with traumatic limb skin defects ≥160 cm².
  • RECELL-assisted autologous skin grafting with mesh grafts under general anesthesia.
  • Assessment of wound healing, scarring (Vancouver Scar Scale), and pain (visual analog scale) up to 24 weeks; primary endpoint: ≥95% reepithelialization by postoperative day 14.

Main Results:

  • Patient recruitment ongoing since April 2024.
  • As of April 10, 2025, 4 out of 10 screened patients were enrolled.
  • No adverse events or protocol deviations have been observed in the enrolled patients.

Conclusions:

  • This study validates the utility of RECELL for traumatic skin defects, focusing on wound closure and scar formation.
  • Further assessment includes adverse events, healing time, infection, and durability.
  • Findings will inform future randomized controlled trials on RECELL for trauma reconstruction.