Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormones Regulating Blood Glucose01:16

Hormones Regulating Blood Glucose

6.4K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
6.4K
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors01:19

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors

521
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
521
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

858
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
858
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

822
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
822
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

3.8K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
3.8K
Oral Hypoglycemic Agents: Glinides01:06

Oral Hypoglycemic Agents: Glinides

593
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
593

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cost-effectiveness of control-IQ automated insulin delivery in adults with type 1 diabetes in Sweden.

Diabetic medicine : a journal of the British Diabetic Association·2026
Same author

Cost-Effectiveness of Control-IQ+ Technology in Insulin-Treated Patients With Type 2 Diabetes in the United States.

Diabetes, obesity & metabolism·2026
Same author

Safety of Inhaled Insulin in Adults with Diabetes.

Diabetes technology & therapeutics·2026
Same author

A Real-World Data Assessment of Pulmonary Toxicity of Inhaled Insulin for Diabetes.

Diabetes technology & therapeutics·2026
Same author

Psychosocial outcomes among adults with type 1 diabetes using a tubeless automated insulin delivery system compared with sensor augmented pump therapy: A randomised, parallel-group clinical trial sub-study.

Diabetes, obesity & metabolism·2026
Same author

Automated basal insulin delivery versus multiple daily injections in type 1 diabetes: results from a randomized parallel controlled trial.

Frontiers in endocrinology·2026
Same journal

Prescription drug prior authorization: costs to pharmacies and physicians.

The American journal of managed care·2026
Same journal

Combined pharmacotherapy and psychotherapy impact on opioid use disorder treatment.

The American journal of managed care·2026
Same journal

The societal costs of food insecurity: implications for managed care strategies.

The American journal of managed care·2026
Same journal

Availability of hospital financial assistance documents in non-English languages.

The American journal of managed care·2026
Same journal

Real-world weight loss with injectable semaglutide vs dulaglutide for diabetes.

The American journal of managed care·2026
Same journal

Social needs screening and supplemental benefits in Medicare Advantage.

The American journal of managed care·2026
See all related articles

Related Experiment Video

Updated: Jan 13, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.3K

HEDIS glycemic goal achieved using control-IQ Technology.

Bimal V Patel, Sharon M Wang1, Laurel H Messer

  • 1Tandem Diabetes Care, 12400 High Bluff Dr, San Diego, CA 92130.

The American Journal of Managed Care
|January 9, 2026
PubMed
Summary
This summary is machine-generated.

Switching to automated insulin delivery (AID) therapy significantly improved glycemic control in individuals with type 1 diabetes (T1D). More patients achieved target glucose levels, reducing instances of poor glycemic control.

More Related Videos

A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli
08:01

A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli

Published on: August 12, 2016

9.4K
Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

11.5K

Related Experiment Videos

Last Updated: Jan 13, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.3K
A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli
08:01

A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli

Published on: August 12, 2016

9.4K
Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

11.5K

Area of Science:

  • Endocrinology and Metabolism
  • Diabetes Technology
  • Public Health and Quality Measures

Background:

  • Type 1 diabetes (T1D) management often involves multiple daily insulin injections (MDI).
  • Automated insulin delivery (AID) systems offer advanced glycemic control solutions.
  • Healthcare Effectiveness Data and Information Set (HEDIS) measures assess glycemic status using HbA1c and glucose management indicator (GMI).

Purpose of the Study:

  • To evaluate the impact of switching from MDI to Control-IQ AID on glycemic control in T1D.
  • To assess changes in glucose management indicator (GMI) and hemoglobin A1c (HbA1c) at 12 months post-transition.
  • To compare achievement of HEDIS and American Diabetes Association (ADA) glycemic targets across different payer types.

Main Methods:

  • Retrospective analysis of US-based data from 12,522 individuals with T1D.
  • Inclusion criteria: prior MDI use, ≥1 year on Control-IQ, baseline HbA1c within 6 months of initiation, and ≥70% continuous glucose monitoring use.
  • Primary outcome: change in proportion meeting HEDIS (<8% HbA1c/GMI) and ADA (<7% GMI) targets, analyzed by payer (commercial, Medicaid, Medicare).

Main Results:

  • Significant improvement in meeting HEDIS quality standards, increasing from 49.6% to 92.9% at 12 months post-AID initiation.
  • Similar improvements observed for those achieving <7% GMI.
  • Dramatic reduction in poor glycemic control (HbA1c >9%), decreasing from 3431 to 15 individuals (a 99.6% decrease) across all payer groups.

Conclusions:

  • Control-IQ AID therapy enables a substantially higher proportion of individuals with T1D to achieve glycemic targets compared to MDI.
  • Improved glycemic control was consistent across commercial, Medicaid, and Medicare payer groups.
  • AID technology represents a significant advancement in achieving optimal glycemic status for individuals with T1D.