Related Experiment Video
Updated: Jan 13, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
Activity standardization and determination of the half-life of Tb-161
N Lisowska1, J Marganiec-Gałązka1, M Czudek1
1National Centre for Nuclear Research, Radioisotope Centre POLATOM, Andrzeja Sołtana 7, 05-400, Otwock, Poland.
Abstract:
Terbium-161 is widely researched as a candidate for applications in nuclear medicine, creating an urgent need for precise activity determinations and accurate nuclear data. In this work, the activity of Tb-161 was measured using three LSC methods - 4πβ-γ-coincidence counting, TDCR and CIEMAT-NIST, giving consistent results. The half-life of the radionuclide was determined in a measurement campaign performed over approximately 42 days using two TDCR systems. The obtained result of 6.9618(18) days validates the recently reported values in literature data and confirms that the half-life of Tb-161 is higher than the currently recommended value of 6.89(2) days (Reich, 2011).
Related Concept Videos
Radioactive Decay and Radiometric Dating
Half-life of a Reaction
One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...

